Article
The presence of two distinct 8-oxoguanine repair enzymes in human cells: their potential complementary roles in preventing mutation.
Nucleic acids research - 15 Nov 1998
Hazra T K, Izumi T, Maidt L, Floyd R A, Mitra S
Abstract excerpt
8-Oxoguanine (8-oxoG), induced by reactive oxygen species (ROS) and ionizing radiation, is arguably the most important mutagenic lesion in DNA. This oxidized base, because of its mispairing with A, induces GC-->TA transversion mutations often observed spontaneously in tumor cells. The human cDNA...
Topics
- Carbon-Oxygen Lyases
- Cell Line
- DNA
- DNA Damage
- DNA Glycosylases
- DNA Ligases
- DNA Repair
- DNA-(Apurinic or Apyrimidinic Site) Lyase
- Deoxyribonuclease IV (Phage T4-Induced)
- GTP-Binding Proteins
- Guanine
- HeLa Cells
- Humans
- Mutation
- N-Glycosyl Hydrolases