Article
The presence of two distinct 8-oxoguanine repair enzymes in human cells: their potential complementary roles in preventing mutation.
Nucleic acids research - 15 Nov 1998
Hazra T K, Izumi T, Maidt L, Floyd R A, Mitra S
Abstract excerpt
8-Oxoguanine (8-oxoG), induced by reactive oxygen species (ROS) and ionizing radiation, is arguably the most important mutagenic lesion in DNA. This oxidized base, because of its mispairing with A, induces GC-->TA transversion mutations often observed spontaneously in tumor cells. The human cDNA encoding the repair enzyme 8-oxoG-DNA glycosylase (OGG-1) has recently been cloned, however, its activity was never...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.