Article
A comparative study of the biochemical properties of human and mouse recombinant O6-methylguanine-DNA methyltransferases.
Carcinogenesis - 1 Feb 1995
Roy R, Shiota S, Kennel S J, Raha R, von Wronski M, Brent T P, Mitra S
Abstract excerpt
The O6-methylguanine-DNA methyltransferase (MGMT) repairs mutagenic and carcinogenic O6-alkylguanine in DNA by accepting stoichiometrically the alkyl group from the base. Although the mouse MGMT is larger than the human protein because of an additional tetrapeptide sequence, these proteins are 70...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Monoclonal
- Cattle
- Cellulose
- DNA
- Epitope Mapping
- Humans
- Isoelectric Point
- Kinetics
- Methyltransferases
- Mice
- Molecular Sequence Data
- Molecular Weight
- Mutation
- O(6)-Methylguanine-DNA Methyltransferase
- Precipitin Tests
- RNA