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Article

Enhanced in vivo repair of O(4)-methylthymine by a mutant human DNA alkyltransferase.

Carcinogenesis - 1 Jul 2000

Encell L P, Loeb L A

Abstract excerpt

The repair of O(6)-methylguanine (m(6)G) by human O(6)-alkylguanine-DNA alkyltransferase (hAGT) is approximately 5000-fold greater than that for O(4)-methylthymine (m(4)T). To evaluate each adduct's contribution to mutagenesis, we previously created a mutant hAGT with increased specificity for m(4)T in vitro. The mutant and wild-type (WT) hAGT have now been expressed in bacterial strains that allow for the...

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PMID: 10874019

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