Article
Proliferation of chicken neuroretina cells induced by v-src, in vitro, depends on activation of the E2F transcription factor.
Oncogene - 3 Jul 1997
Pasteau S, Loiseau L, Brun G
Abstract excerpt
Quiescent chicken or quail retina neuroblasts (NR) can be induced to proliferate actively, in culture, by the v-src oncoprotein. The chE2F-1 transcription factor, a physiological partner of the retinoblastoma gene product, is highly expressed in vivo, in dividing chicken neuroretina cells (CNR). It is sharply down-regulated as cells enter the post-mitotic differentiation stage, thus suggesting that E2F activity...
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