The stimulation of quiescent rat fibroblasts by v-src and v-fps oncogenic protein-tyrosine kinases leads to the induction of a subset of immediate early genes.

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Article

The stimulation of quiescent rat fibroblasts by v-src and v-fps oncogenic protein-tyrosine kinases leads to the induction of a subset of immediate early genes.

Oncogene - 1 Jul 1991

Jähner D, Hunter T

Abstract excerpt

The stimulation of quiescent murine fibroblasts by growth factors and by phorbol esters results in a rapid and transient transcriptional activation of a large group of so-called immediate early genes. Several such genes were found to be induced in chicken embryo fibroblasts following activation of a temperature sensitive (ts) Rous sarcoma virus v-src mutant following temperature shift (Simmons et al., 1989). In...

Topics

Animals
Cattle
Cell Line
Cloning, Molecular
Cycloheximide
DNA
Epidermal Growth Factor
Fetal Blood
Fibroblasts
Fusion Proteins, gag-onc
Gene Expression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, src

Mutation

Phorbol 12,13-Dibutyrate

Protein-Tyrosine Kinases

RNA, Messenger

Rats

Temperature

Source

Open in PubMed

Identifiers

PMID: 1861868

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1861868-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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