Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

8-Hydroxyguanine (7,8-dihydro-8-oxoguanine) in hot spots of the c-Ha-ras gene: effects of sequence contexts on mutation spectra.

Carcinogenesis - 1 Apr 1995

Kamiya H, Murata-Kamiya N, Koizume S, Inoue H, Nishimura S, Ohtsuka E

Abstract excerpt

We previously reported that 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) at the second position of codon 12 of the c-Ha-ras gene induces many types of mutations in NIH3T3 cells. In this study we incorporated the modified base into the first and second positions of codon 12 in the coding strand and into the first position of codon 61 in the non-coding strand of the gene using a new 8-hydroxyguanine phosphoramidite...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to Gene Expression Regulation

Share to Molecular Sequence Data

Share to Mutation

Share to Transfection

Source

Identifiers

PMID: 7728970
DOI: 10.1093/carcin/16.4.883

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

8-Hydroxyguanine (7,8-dihydro-8-oxoguanine) in hot spots of the c-Ha-ras gene: effects of sequence contexts on mutation spectra.PMID 7728970Read ↗

c-Ha-ras containing 8-hydroxyguanine at codon 12 induces point mutations at the modified and adjacent positions.Semantic proximity Read ↗

Mutations induced by DNA lesions in hot spots of the c-Ha-ras gene.Semantic proximity Read ↗

O6-ethylguanine and O6-benzylguanine incorporated site-specifically in codon 12 of the rat H-ras gene induce semi-targeted as well as targeted mutations in Rat4 cells.Semantic proximity Read ↗

An abasic site analogue activates a c-Ha-ras gene by a point mutation at modified and adjacent positions.Semantic proximity Read ↗

Mutagenicity of a unique 8-oxoguanine in a human Ha-ras sequence in mammalian cells.Semantic proximity Read ↗

Preferential DNA Damage and Poor Repair Determine ras Gene Mutational Hotspot in Human CancerSemantic proximity Read ↗

Correlation of (6-4)photoproduct formation with transforming mutations in UV-irradiated Ha-ras.Semantic proximity Read ↗

Preferential carcinogen-DNA adduct formation at codons 12 and 14 in the human K-ras gene and their possible mechanisms.Semantic proximity Read ↗

Nonrandom distribution of O6-methylguanine in H-ras gene sequence from DNA modified with N-methyl-N-nitrosourea.Semantic proximity Read ↗

Transforming activity of a synthetic c-Ha-ras gene containing O6-methylguanine in codon 12.Semantic proximity Read ↗

Codon 64 of K-ras gene mutation pattern in hepatocellular carcinomas induced by bleomycin and 1-nitropyrene in A/J mice.Semantic proximity Read ↗

Codons 12 and 13 of H-ras protooncogene interrupt the progression of DNA synthesis catalyzed by DNA polymerase alpha.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.