Article
Conserved cysteine residues of Oct-2 POU domain confer sensitivity to oxidation but are dispensable for sequence-specific DNA binding.
Biochimica et biophysica acta - 28 May 1993
Rigoni P, Xu L, Harshman K, Schaffner W, Arnosti D N
Abstract excerpt
The POU family of proteins, including the Oct-2 transcription factor, is characterized by a highly conserved bipartite DNA binding domain containing a 'POU homeodomain', distantly related to homeodomains of other DNA binding proteins, and a 'POU specific' domain unique to this class of factors. P...
Topics
- Amino Acid Sequence
- Base Sequence
- Conserved Sequence
- Cysteine
- DNA-Binding Proteins
- Humans
- Molecular Sequence Data
- Mutation
- Octamer Transcription Factor-2
- Oxidation-Reduction
- Structure-Activity Relationship
- Transcription Factors