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Article

The DNA binding domain (POU domain) of transcription factor oct-1 suffices for stimulation of DNA replication.

The EMBO journal - 1 Jun 1990

Verrijzer C P, Kal A J, Van der Vliet P C

Abstract excerpt

Oct-1, also referred to as NFIII, OTF-1, OBP100 or NF-A1, is a ubiquitous sequence-specific DNA binding protein that activates transcription and adenovirus DNA replication. The protein contains a conserved DNA binding domain (POU domain) present in several transcription factors. We have overproduced oct-1, the related oct-2 and several oct-1 deletion mutants in a vaccinia expression system to identify the domains...

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Source

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Identifiers

PMID: 2347308
DOI: 10.1002/j.1460-2075.1990.tb08314.x
PMCID: PMC551894

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The DNA binding domain (POU domain) of transcription factor oct-1 suffices for stimulation of DNA replication.PMID 2347308Read ↗

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Herpes simplex virus infections are arrested in Oct-1-deficient cellsSemantic proximity Read ↗

OCT4 Negatively Regulates the Transcriptional Programming of the Early Region 3 Immune Evasion Genes of Human AdenovirusSemantic proximity Read ↗

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Conserved cysteine residues of Oct-2 POU domain confer sensitivity to oxidation but are dispensable for sequence-specific DNA binding.Semantic proximity Read ↗

The POU-specific domain of Pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1-Pit-1 interactions.Semantic proximity Read ↗

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B-Cell coactivator OBF-1 exhibits unusual transcriptional properties and functions in a DNA-bound Oct-1-dependent fashion.Semantic proximity Read ↗

The POU domain: versatility in transcriptional regulation by a flexible two-in-one DNA-binding domain.Semantic proximity Read ↗

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