Article
Redox regulation of the embryonic stem cell transcription factor oct-4 by thioredoxin.
Stem cells (Dayton, Ohio) - 1 Jan 2004
Guo Ying, Einhorn Lawrence, Kelley Mark, Hirota Kiichi, Yodoi Junji, Reinbold Rolland, Scholer Hans, Ramsey Heather, Hromas Robert
Abstract excerpt
Oct-4 is a transcriptional regulator required to maintain the totipotentiality of embryonic stem (ES) cells. Downregulation of its activity is required for proper differentiation of the blastocyst during uterine implantation. Uterine implantation and subsequent vascularization increase oxygen exposure of the developing embryo, thereby altering the intracellular reduction-oxidation status. We tested whether Oct-4...
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