Article
The Oct-1 POU domain activates snRNA gene transcription by contacting a region in the SNAPc largest subunit that bears sequence similarities to the Oct-1 coactivator OBF-1.
Genes & development - 15 Nov 1998
Ford E, Strubin M, Hernandez N
Abstract excerpt
The RNA polymerases II and III snRNA gene promoters contain an octamer sequence as part of the enhancer and a proximal sequence element (PSE) as part of the core promoter. The octamer and the PSE bind the POU domain activator Oct-1 and the basal transcription factor SNAPc, respectively. Oct-1, bu...
Topics
- Amino Acid Sequence
- Binding Sites
- DNA Probes
- DNA-Binding Proteins
- Homeodomain Proteins
- Host Cell Factor C1
- Humans
- Molecular Sequence Data
- Mutation
- Octamer Transcription Factor-1
- Promoter Regions, Genetic
- Protein Binding
- RNA Polymerase II
- RNA Polymerase III
- RNA, Small Nuclear