The POU-specific domain of Pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1-Pit-1 interactions.

doi:10.1016/0092-8674(90)90067-o

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Article

The POU-specific domain of Pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1-Pit-1 interactions.

Cell - 15 Jun 1990

Ingraham H A, Flynn S E, Voss J W, Albert V R, Kapiloff M S, Wilson L, Rosenfeld M G

Abstract excerpt

Pit-1 is a member of a family of transcription factors sharing two regions of homology: a highly conserved POU-specific (POUS) domain and a more divergent homeodomain (POUHD). Analysis of mutant Pit-1 proteins suggests that, while the POUHD is required and sufficient for low affinity DNA binding,...

Topics

Algorithms
Animals
Base Sequence
Binding Sites
DNA
DNA-Binding Proteins
Kinetics
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides
Oligonucleotide Probes
Plasmids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Protein Binding

Protein Conformation

Restriction Mapping

Transcription Factor Pit-1

Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 2350782
DOI: 10.1016/0092-8674(90)90067-o

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2350782-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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