A genome-wide search for genes predisposing to manic-depression, assuming autosomal dominant inheritance.

Article

A genome-wide search for genes predisposing to manic-depression, assuming autosomal dominant inheritance.

American journal of human genetics - 1 Jun 1993

Coon H, Jensen S, Hoff M, Holik J, Plaetke R, Reimherr F, Wender P, Leppert M, Byerley W

Abstract excerpt

Manic-depressive illness (MDI), also known as "bipolar affective disorder," is a common and devastating neuropsychiatric illness. Although pivotal biochemical alterations underlying the disease are unknown, results of family, twin, and adoption studies consistently implicate genetic transmission...

Topics

Adult
Bipolar Disorder
Chromosome Mapping
Genes, Dominant
Genetic Linkage
Genetic Markers
Genome, Human
Genotype
Humans
Lod Score
Pedigree

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