Article
A genome-wide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish.
Nature genetics - 1 Apr 1996
Ginns E I, Ott J, Egeland J A, Allen C R, Fann C S, Pauls D L, Weissenbachoff J, Carulli J P, Falls K M, Keith T P, Paul S M
Abstract excerpt
The most characteristic features of bipolar affective disorder (manic-depressive illness) are episodes of mania (bipolar I, BPI) or hypomania (bipolar II, BPII) interspersed with periods of depression. Manic-depressive illness afflicts about one percent of the population, and if untreated, is associated with an approximately 20% risk of suicide. Twin, family and adoption studies provide compelling evidence for a...
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