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Article

Structural basis of amino acid alpha helix propensity.

Science (New York, N.Y.) - 11 Jun 1993

Blaber M, Zhang X J, Matthews B W

Abstract excerpt

The propensity of an amino acid to form an alpha helix in a protein was determined by multiple amino substitutions at positions 44 and 131 in T4 lysozyme. These positions are solvent-exposed sites within the alpha helices that comprise, respectively, residues 39 to 50 and 126 to 134. Except for two acidic substitutions that may be involved in salt bridges, the changes in stability at the two sites agree well. The...

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Identifiers

PMID: 8503008
DOI: 10.1126/science.8503008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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