Article
Structural basis of amino acid alpha helix propensity.
Science (New York, N.Y.) - 11 Jun 1993
Blaber M, Zhang X J, Matthews B W
Abstract excerpt
The propensity of an amino acid to form an alpha helix in a protein was determined by multiple amino substitutions at positions 44 and 131 in T4 lysozyme. These positions are solvent-exposed sites within the alpha helices that comprise, respectively, residues 39 to 50 and 126 to 134. Except for t...
Topics
- Amino Acids
- Bacteriophage T4
- Enzyme Stability
- Models, Molecular
- Muramidase
- Mutation
- Protein Structure, Secondary
- Thermodynamics