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Article

Relationship between amino acid properties and protein stability: buried mutations.

Journal of protein chemistry - 1 Jul 1999

Gromiha M M, Oobatake M, Kono H, Uedaira H, Sarai A

Abstract excerpt

In order to understand the mechanism of protein stability and to develop a simple method for predicting mutation-induced stability changes, we analyzed the relationship between stability changes caused by buried mutations and changes in 48 amino acid properties. As expected from the importance of hydrophobicity, properties reflecting hydrophobicity are strongly correlated with the stability of proteins. We found...

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PMID: 10524774
DOI: 10.1023/a:1020603401001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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