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Article

Alanine-scanning mutagenesis of the beta-sheet region of phage T4 lysozyme suggests that tertiary context has a dominant effect on beta-sheet formation.

Protein science : a publication of the Protein Society - 1 Oct 2004

He Molly M, Wood Zachary A, Baase Walter A, Xiao Hong, Matthews Brian W

Abstract excerpt

In general, alpha-helical conformations in proteins depend in large part on the amino acid residues within the helix and their proximal interactions. For example, an alanine residue has a high propensity to adopt an alpha-helical conformation, whereas that of a glycine residue is low. The sequence preferences for beta-sheet formation are less obvious. To identify the factors that influence beta-sheet...

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Identifiers

PMID: 15340171
DOI: 10.1110/ps.04875504
PMCID: PMC2286564

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Source receipt: pubmed, retrieved 7 Sept 2026.

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