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Article

Stabilizing and destabilizing effects of placing beta-branched amino acids in protein alpha-helices.

Biochemistry - 11 Oct 1994

Cornish V W, Kaplan M I, Veenstra D L, Kollman P A, Schultz P G

Abstract excerpt

In order to gain greater insight into the effects of beta-branched amino acids on protein alpha-helices, hydrophobic amino acids with varying degrees of beta-branching, including the fully beta-substituted L-2-amino-3,3-dimethylbutanoic acid (ADBA), were incorporated into the protein T4 lysozyme. The unnatural and natural amino acids were substituted at two solvent-exposed alpha-helical sites, Ser 44 and Asn 68,...

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PMID: 7918421
DOI: 10.1021/bi00206a003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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