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Article

Stereochemical criteria for prediction of the effects of proline mutations on protein stability.

PLoS computational biology - 1 Dec 2007

Bajaj Kanika, Madhusudhan M S, Adkar Bharat V, Chakrabarti Purbani, Ramakrishnan C, Sali Andrej, Varadarajan Raghavan

Abstract excerpt

When incorporated into a polypeptide chain, proline (Pro) differs from all other naturally occurring amino acid residues in two important respects. The phi dihedral angle of Pro is constrained to values close to -65 degrees and Pro lacks an amide hydrogen. Consequently, mutations which result in introduction of Pro can significantly affect protein stability. In the present work, we describe a procedure to...

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Identifiers

PMID: 18069886
DOI: 10.1371/journal.pcbi.0030241
PMCID: PMC2134964

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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