Tolerance of T4 lysozyme to proline substitutions within the long interdomain alpha-helix illustrates the adaptability of proteins to potentially destabilizing lesions.

Article

Tolerance of T4 lysozyme to proline substitutions within the long interdomain alpha-helix illustrates the adaptability of proteins to potentially destabilizing lesions.

The Journal of biological chemistry - 5 Feb 1992

Sauer U H, San D P, Matthews B W

Abstract excerpt

To investigate the ability of a protein to accommodate potentially destabilizing amino acid substitutions, and also to investigate the steric requirements for catalysis, proline was substituted at different sites within the long alpha-helix that connects the amino-terminal and carboxyl-terminal d...

Topics

Catalysis
Muramidase
Mutation
Proline
Protein Conformation
Proteins
T-Phages
Temperature
X-Ray Diffraction

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