Increasing protein conformational stability by optimizing beta-turn sequence.

Abstract excerpt

Protein conformational stability is an important concern in many fields. Here, we describe a strategy for significantly increasing conformational stability by optimizing beta-turn sequence. Proline and glycine residues are statistically preferred at several beta-turn positions, presumably because their unique side-chains contribute favorably to conformational stability in certain beta-turn positions. However,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Glycine
• Share to Models, Molecular
• Share to Mutation