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Article

Importance of mutant position in Ramachandran plot for predicting protein stability of surface mutations.

Biopolymers - 5 Aug 2002

Gromiha M Michael, Oobatake Motohisa, Kono Hidetoshi, Uedaira Hatsuho, Sarai Akinori

Abstract excerpt

Understanding the mechanisms by which mutations affect protein stability is one of the most important problems in molecular biology. In this work, we analyzed the relationship between changes in protein stability caused by surface mutations and changes in 49 physicochemical, energetic, and conformational properties of amino acid residues. We found that the hydration entropy was the major contributor to the...

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PMID: 12115138
DOI: 10.1002/bip.10125

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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