Article
A stem cell niche theory of intestinal crypt maintenance based on a study of somatic mutation in colonic mucosa.
The American journal of pathology - 1 Oct 1992
Williams E D, Lowes A P, Williams D, Williams G T
Abstract excerpt
In both large and small intestine, mutagen administration leads to the occurrence of isolated crypts that are completely populated by a mutated phenotype; therefore, it has been proposed that crypts are maintained by a single stem cell. We show in mice that a single dose of mutagen leads to an early transient increase in frequency of colonic crypts that show a partial mutated phenotype and a later increase in...
Topics
- Animals
- Cell Division
- Colon
- Dimethylhydrazines
- Ethylnitrosourea
- Glucosephosphate Dehydrogenase
- Histocytochemistry
- Intestinal Mucosa
- Male
- Mice
- Mice, Inbred C3H