Intestinal crypt properties fit a model that incorporates replicative ageing and deep and proximate stem cells.

doi:10.1111/j.1365-2184.2006.00395.x

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Article

Intestinal crypt properties fit a model that incorporates replicative ageing and deep and proximate stem cells.

Cell proliferation - 1 Oct 2006

Lobachevsky P N, Radford I R

Abstract excerpt

A model of intestinal crypt organization is suggested based on the assumption that stem cells have a finite replicative life span. The model assumes the existence in a crypt of a quiescent ('deep') stem cell and a few more actively cycling ('proximate') stem cells. Monte Carlo computer simulation of published intestinal crypt mutagenesis data is used to test the model. The results of the simulation indicate that...

Topics

Animals
Cell Division
Cellular Senescence
Colon
Computer Simulation
Epithelial Cells
Humans
Intestinal Mucosa
Intestine, Small
Mice
Models, Biological
Monte Carlo Method
Mutagenesis
Phenotype
Stem Cells

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Identifiers

PMID: 16987140
DOI: 10.1111/j.1365-2184.2006.00395.x
PMCID: PMC6760706

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