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An integrative computational model for intestinal tissue renewal

20 Jul 2009

Abstract excerpt

OBJECTIVES: The luminal surface of the gut is lined with a monolayer of epithelial cells that acts as a nutrient absorptive engine and protective barrier. To maintain its integrity and functionality, the epithelium is renewed every few days. Theoretical models are powerful tools that can be used to test hypotheses concerning the regulation of this renewal process, to investigate how its dysfunction can lead to...

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PMID: 19622103
DOI: 10.1111/j.1365-2184.2009.00627.x

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