Article
Mitogenic and dedifferentiating effect of the K-fgf/hst oncogene on rat thyroid PC clone 3 epithelial cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Mar 1993
Battaglia C, Berlingieri M T, Martelli M L, Trapasso F, Delli Bovi P, Fusco A
Abstract excerpt
Transfection of rat thyroid differentiated epithelial cells, PC clone 3, with the K-fgf/hst oncogene results in alleviation of thyrotropin dependency for growth and suppression of the differentiated phenotype without the acquisition of the fully transformed phenotype. An autocrine mechanism is responsible for these effects, since the proliferation of PC clone 3 cells, induced by K-FGF-conditioned medium, is...
Topics
- Animals
- Cell Differentiation
- Cell Division
- Cell Line
- Clone Cells
- Culture Media, Conditioned
- Epithelial Cells
- Epithelium
- Fibroblast Growth Factor 1
- Fibroblast Growth Factor 2