Article
Molecular Analysis of Human Prorenin Prosegment Variants in Vitro and in Vivo
1 Jul 1995
Abstract excerpt
The aspartyl protease renin, an important modulator of blood pressure in humans, is present in the circulation not only in its active form, but also as an inactive precursor, prorenin, in which a 43-amino acid prosegment blocks access of the substrate to the active site of the enzyme. Site-directed mutagenesis of the prosegment has led to the following conclusions. 1) Maintenance of the enzymatically inactive...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.