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Article

Glycosylation of human proteinase-activated receptor-2 (hPAR2): role in cell surface expression and signalling.

The Biochemical journal - 1 Dec 2002

Compton Steven J, Sandhu Sabrina, Wijesuriya Suranga J, Hollenberg Morley D

Abstract excerpt

We have analysed the role of N-linked glycosylation in regulating human proteinase-activated receptor-2 (hPAR(2)) expression and function. Epitope-tagged wild-type hPAR(2) (wt-hPAR(2)) or hPAR(2) that lacked glycosylation sequons (following site-directed mutagenesis) in either the N-terminus [hPAR(2)N30A (Asn(30)-->Ala)], extracellular loop 2 [ECL2; hPAR(2)N222Q (Asn(222)-->Gln) or hPAR(2)N222A (Asn(222)-->Ala)]...

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Identifiers

PMID: 12171601
DOI: 10.1042/BJ20020706
PMCID: PMC1222997

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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