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Article

(Arg)3 within the N-terminal domain of glucosidase I contains ER targeting information but is not required absolutely for ER localization.

Glycobiology - 1 Mar 2003

Hardt Birgit, Kalz-Fuller Burga, Aparicio Raquel, Volker Christof, Bause Ernst

Abstract excerpt

Glucosidase I is an endoplasmic reticulum (ER) type II membrane enzyme that cleaves the distal alpha1,2-glucose of the asparagine-linked GlcNAc2-Man9-Glc3 precursor. To identify sequence motifs responsible for ER localization, we prepared a protein chimera by transferring the cytosolic and transmembrane domain of glucosidase I to the luminal domain of Golgi-Man9-mannosidase. The GIM9 hybrid was overexpressed in...

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PMID: 12626409
DOI: 10.1093/glycob/cwg013

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Source receipt: pubmed, retrieved 7 Sept 2026.

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