Article
Effect of the non-conserved N-terminus on the DNA binding activity of the yeast TATA binding protein.
Nucleic acids research - 25 Apr 1993
Kuddus R, Schmidt M C
Abstract excerpt
We have studied the DNA binding activity of recombinant yeast TATA Binding Protein (TBP) with particular interest in the role played by the non-conserved N-terminal domain. By comparing the DNA binding activity of wild type yeast TBP with a mutant form of TBP that lacks the non-conserved N-terminal domain (TBP delta 57), we have determined that the N-terminus of TBP alters both the shape and the stability of the...
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