Article
The activation region of the Tat protein of human immunodeficiency virus type-1 functions in yeast.
Nucleic acids research - 25 Apr 1994
Subramanian T, D'Sa-Eipper C, Elangovan B, Chinnadurai G
Abstract excerpt
The N-terminal 48 amino acids of the Tat protein of human immunodeficiency virus type (HIV)-1 constitute its activation region. This region can autonomously activate transcription when targeted to the HIV-1 long terminal repeat or certain heterologous promoters either through DNA binding sites located upstream of the transcription initiation site or via downstream RNA binding sites in mammalian cells. To...
Topics
- Gene Products, tat
- HIV-1
- Mutation
- Precipitin Tests
- Promoter Regions, Genetic
- Recombinant Fusion Proteins
- Regulatory Sequences, Nucleic Acid
- Saccharomyces cerevisiae
- Transcriptional Activation
- tat Gene Products, Human Immunodeficiency Virus