Article
Clues to the pathogenesis of familial colorectal cancer.
Science (New York, N.Y.) - 7 May 1993
Aaltonen L A, Peltomäki P, Leach F S, Sistonen P, Pylkkänen L, Mecklin J P, Järvinen H, Powell S M, Jen J, Hamilton S R
Abstract excerpt
A predisposition to colorectal cancer is shown to be linked to markers on chromosome 2 in some families. Molecular features of "familial" cancers were compared with those of sporadic colon cancers. Neither the familial nor sporadic cancers showed loss of heterozygosity for chromosome 2 markers, and the incidence of mutations in KRAS, P53, and APC was similar in the two groups of tumors. Most of the familial...
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