GENETICS OF COLON CANCER: Impact of Inheritance on Colon Cancer Risk

doi:10.1146/annurev.med.46.1.371

Article

GENETICS OF COLON CANCER: Impact of Inheritance on Colon Cancer Risk

1 Feb 1995

Abstract excerpt

The genes that are mutated in two of the rare syndromes of hereditary colon cancer were recently identified, and genetic diagnosis is already possible in some cases. Acquired mutations of these same genes also appear to be important in sporadic colon cancers. Familial clustering of sporadic cases is common and may likewise arise from inherited susceptibility. Screening strategies for both the rare syndromes and...

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