Article
Mechanism of carcinogenesis in familial tumors.
International journal of clinical oncology - 1 Aug 2004
Tamura Kazuo, Utsunomiya Joji, Iwama Takeo, Furuyama Jun-ichi, Takagawa Tetsuya, Takeda Naohisa, Fukuda Yoshihiro, Matsumoto Takayuki, Nishigami Takashi, Kusuhara Kiyoshi, Sagayama Ken, Nakagawa Kazuhiko, Yamamura Takehira
Abstract excerpt
It is thought that malignant tumors occur through interactions of multiple environmental factors and a personal genetic factor. A normal somatic cell having an intrinsic function is able to acquire the characteristics of a malignant cell under the influence of many factors. A small percentage of all tumors have obvious familial aggregation. These entities are called familial cancer. The familial cancer syndrome...
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