Article
Haloperidol disposition is dependent on debrisoquine hydroxylation phenotype.
Therapeutic drug monitoring - 1 Apr 1992
Llerena A, Alm C, Dahl M L, Ekqvist B, Bertilsson L
Abstract excerpt
To investigate the importance of genetic factors for the regulation of haloperidol metabolism, we studied the disposition of a single oral dose of this drug in a panel of six extensive (EM) and six poor (PM) metabolizers of debrisoquine. PM eliminated haloperidol significantly slower than EM, the...
Topics
- Adult
- Chromatography, High Pressure Liquid
- Debrisoquin
- Female
- Half-Life
- Haloperidol
- Humans
- Hydroxylation
- Male
- Middle Aged
- Phenotype