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Article

Haloperidol disposition is dependent on debrisoquine hydroxylation phenotype.

Therapeutic drug monitoring - 1 Apr 1992

Llerena A, Alm C, Dahl M L, Ekqvist B, Bertilsson L

Abstract excerpt

To investigate the importance of genetic factors for the regulation of haloperidol metabolism, we studied the disposition of a single oral dose of this drug in a panel of six extensive (EM) and six poor (PM) metabolizers of debrisoquine. PM eliminated haloperidol significantly slower than EM, the plasma half-life being longer (mean 29.4 +/- S.D. 4.2 and 16.3 +/- 6.4 h; p less than 0.01) and the clearance lower...

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Source

Identifiers

PMID: 1585408
DOI: 10.1097/00007691-199204000-00003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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