Polymorphic debrisoquin metabolism in a Turkish population.

doi:10.1038/clpt.1994.48

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Article

Polymorphic debrisoquin metabolism in a Turkish population.

Clinical pharmacology and therapeutics - 1 Apr 1994

Bozkurt A, Basci N E, Isimer A, Sayal A, Kayaalp S O

Abstract excerpt

Debrisoquin hydroxylation polymorphism was studied in 326 unrelated healthy Turkish volunteers. Debrisoquin sulfate (10 mg) was administered to subjects, and debrisoquin and 4-hydroxydebrisoquin were determined in the 0- to 8-hour urine samples. Debrisoquin oxidation was polymorphic, with 11 subj...

Topics

Adolescent
Adult
Chromatography, High Pressure Liquid
Debrisoquin
Female
Humans
Male
Oxidation-Reduction
Phenotype
Polymorphism, Genetic
Turkey

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