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Article

Age at onset in Huntington's disease and methylation at D4S95.

Journal of medical genetics - 1 Mar 1993

Reik W, Maher E R, Morrison P J, Harding A E, Simpson S A

Abstract excerpt

Age at onset in Huntington's disease (HD) is variable and is influenced by parental sex, paternal age, and genetic background. Several recent models have tried to explain this variable expressivity by invoking parental imprinting and related aspects of epigenetic inheritance. Some of these mechanisms may result in variable DNA methylation at or near the HD gene. We show here that methylation at D4S95, a locus...

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Identifiers

PMID: 8474105
DOI: 10.1136/jmg.30.3.185
PMCID: PMC1016295

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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