Age at onset in Huntington's disease and methylation at D4S95.

doi:10.1136/jmg.30.3.185

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Article

Age at onset in Huntington's disease and methylation at D4S95.

Journal of medical genetics - 1 Mar 1993

Reik W, Maher E R, Morrison P J, Harding A E, Simpson S A

Abstract excerpt

Age at onset in Huntington's disease (HD) is variable and is influenced by parental sex, paternal age, and genetic background. Several recent models have tried to explain this variable expressivity by invoking parental imprinting and related aspects of epigenetic inheritance. Some of these mechan...

Topics

Adolescent
Adult
Age Factors
Aged
Child
Child, Preschool
Chromosomes, Human, Pair 4
DNA
Electrophoresis, Agar Gel
Female
Gene Expression Regulation
Humans
Huntington Disease
Male
Methylation
Middle Aged
Mutation
Paternal Age

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