Proposed genetic basis of Huntington's disease.

doi:10.1016/0168-9525(90)90206-l

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Article

Proposed genetic basis of Huntington's disease.

Trends in genetics : TIG - 1 Aug 1990

Laird C D

Abstract excerpt

I propose that Huntington's disease (HD) is caused by dominant position-effect variegation, a phenomenon for which new information is available in Drosophila melanogaster. The essential features of this proposal are that (1) the HD mutation is the result of a chromosome alteration that inactivates transcription of a nearby structural gene or genes (cis-inactivation); the combination of this proposed chromosome...

Topics

Adolescent
Adult
Age Factors
Alleles
Animals
Child
Child, Preschool
Chromosomes, Human, Pair 4
Drosophila melanogaster
Epistasis, Genetic
Female
Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes

Genes, Dominant

Genes, Regulator

Heterozygote

Humans

Huntington Disease

Source

Open in PubMed

Identifiers

PMID: 2146788
DOI: 10.1016/0168-9525(90)90206-l

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2146788-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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