Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The normal Huntington disease (HD) allele, or a closely linked gene, influences age at onset of HD.

American journal of human genetics - 1 Jul 1993

Farrer L A, Cupples L A, Wiater P, Conneally P M, Gusella J F, Myers R H

Abstract excerpt

We evaluated the hypothesis that Huntington disease (HD) is influenced by the normal HD allele by comparing transmission patterns of genetically linked markers at the D4S10 locus in the normal parent against age at onset in the affected offspring. Analysis of information from 21 sibships in 14 kindreds showed a significant tendency for sibs who have similar onset ages to share the same D4S10 allele from the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Aging
Share to Alleles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Huntington Disease

Share to Pedigree

Source

Open in PubMed Open full text

Identifiers

PMID: 8317477
PMCID: PMC1682222

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The normal Huntington disease (HD) allele, or a closely linked gene, influences age at onset of HD.PMID 8317477Read ↗

Estimating the probability of de novo HD cases from transmissions of expanded penetrant CAG alleles in the Huntington disease gene from male carriers of high normal alleles (27-35 CAG).Semantic proximity Read ↗

Age at onset in Huntington's disease and methylation at D4S95.Semantic proximity Read ↗

The number of CAG repeats within the normal allele does not influence the age of onset in Huntington's disease.Semantic proximity Read ↗

Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease.Semantic proximity Read ↗

Genetic analysis of candidate genes modifying the age-at-onset in Huntington’s diseaseSemantic proximity Read ↗

Exploring Genetic Factors Involved in Huntington Disease Age of Onset: E2F2 as a New Potential Modifier Gene.Semantic proximity Read ↗

Age of onset in Huntington disease: sex specific influence of apolipoprotein E genotype and normal CAG repeat length.Semantic proximity Read ↗

CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion.Semantic proximity Read ↗

Analysis of the 5' upstream sequence of the Huntington's disease (HD) gene shows six new rare alleles which are unrelated to the age at onset of HD.Semantic proximity Read ↗

From genes to trajectories: mapping genetic influences on Huntington's disease progression.Semantic proximity Read ↗

Interaction of normal and expanded CAG repeat sizes influences age at onset of Huntington diseaseSemantic proximity Read ↗

Common SNP-based haplotype analysis of the 4p16.3 Huntington disease gene region.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.