Article
DNA methylation study of Huntington's disease and motor progression in patients and in animal models.
Nature communications - 10 Sept 2020
Lu Ake T, Narayan Pritika, Grant Matthew J, Langfelder Peter, Wang Nan, Kwak Seung, Wilkinson Hilary, Chen Richard Z, Chen Jian, Simon Bawden C, Rudiger Skye R, Ciosi Marc, Chatzi Afroditi, Maxwell Alastair, Hore Timothy A, Aaronson Jeff, Rosinski Jim, Preiss Alicia, Vogt Thomas F, Coppola Giovanni, Monckton Darren, Snell Russell G, William Yang X, Horvath Steve
Abstract excerpt
Although Huntington's disease (HD) is a well studied Mendelian genetic disorder, less is known about its associated epigenetic changes. Here, we characterize DNA methylation levels in six different tissues from 3 species: a mouse huntingtin (Htt) gene knock-in model, a transgenic HTT sheep model, and humans. Our epigenome-wide association study (EWAS) of human blood reveals that HD mutation status is...
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