Age of onset in Huntington disease: sex specific influence of apolipoprotein E genotype and normal CAG repeat length.

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Article

Age of onset in Huntington disease: sex specific influence of apolipoprotein E genotype and normal CAG repeat length.

Journal of medical genetics - 1 Feb 1999

Kehoe P, Krawczak M, Harper P S, Owen M J, Jones A L

Abstract excerpt

Age of onset (AO) of Huntington disease (HD) is known to be correlated with the length of an expanded CAG repeat in the HD gene. Apolipoprotein E (APOE) genotype, in turn, is known to influence AO in Alzheimer disease, rendering the APOE gene a likely candidate to affect AO in other neurological diseases too. We therefore determined APOE genotype and normal CAG repeat length in the HD gene for 138 HD patients who...

Topics

Age of Onset
Anticipation, Genetic
Apolipoproteins E
Female
Genetic Variation
Genotype
Humans
Huntington Disease
Male
Models, Statistical
Sex Factors
Survival
Trinucleotide Repeats

Source

Open in PubMed Open full text

Identifiers

PMID: 10051007
PMCID: PMC1734310

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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