Article
Age of onset in Huntington disease: sex specific influence of apolipoprotein E genotype and normal CAG repeat length.
Journal of medical genetics - 1 Feb 1999
Kehoe P, Krawczak M, Harper P S, Owen M J, Jones A L
Abstract excerpt
Age of onset (AO) of Huntington disease (HD) is known to be correlated with the length of an expanded CAG repeat in the HD gene. Apolipoprotein E (APOE) genotype, in turn, is known to influence AO in Alzheimer disease, rendering the APOE gene a likely candidate to affect AO in other neurological diseases too. We therefore determined APOE genotype and normal CAG repeat length in the HD gene for 138 HD patients who...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
