Evidence for a modifier of onset age in Huntington disease linked to the HD gene in 4p16.

doi:10.1007/s10048-004-0175-2

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Article

Evidence for a modifier of onset age in Huntington disease linked to the HD gene in 4p16.

Neurogenetics - 1 Jun 2004

Djoussé Luc, Knowlton Beth, Hayden Michael R, Almqvist Elisabeth W, Brinkman Ryan R, Ross Christopher A, Margolis Russel L, Rosenblatt Adam, Durr Alexandra, Dode Catherine, Morrison Patrick J, Novelletto Andrea, Frontali Marina, Trent Ronald J A, McCusker Elizabeth, Gómez-Tortosa Estrella, Mayo Cabrero David, Jones Randi, Zanko Andrea, Nance Martha, Abramson Ruth K, Suchowersky Oksana, Paulsen Jane S, Harrison Madaline B, Yang Qiong, Cupples L Adrienne, Mysore Jayalakshmi, Gusella James F, MacDonald Marcy E, Myers Richard H

Abstract excerpt

Huntington disease (HD) is a neurodegenerative disorder caused by the abnormal expansion of CAG repeats in the HD gene on chromosome 4p16.3. A recent genome scan for genetic modifiers of age at onset of motor symptoms (AO) in HD suggests that one modifier may reside in the region close to the HD...

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PMID: 15029481
DOI: 10.1007/s10048-004-0175-2
PMCID: PMC1866166

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MSX1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15029481-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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