Patterns of inheritance of the symptoms of Huntington's disease suggestive of an effect of genomic imprinting.

doi:10.1136/jmg.28.4.224

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Article

Patterns of inheritance of the symptoms of Huntington's disease suggestive of an effect of genomic imprinting.

Journal of medical genetics - 1 Apr 1991

Ridley R M, Frith C D, Farrer L A, Conneally P M

Abstract excerpt

The interaction of symptomatology (rigidity/chorea) in Huntington's disease (HD) with age of onset (AO) was examined using data from the Research Roster for Huntington's Disease Patients and Families. It was shown that AO varies between families and between paternal and maternal transmission and...

Topics

Adolescent
Adult
Age Factors
Alleles
Gene Expression
Genetic Variation
Humans
Huntington Disease
Methylation
Pedigree
Surveys and Questionnaires

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