A generalized estimating equations approach to fitting major gene models in segregation analysis of continuous phenotypes.

doi:10.1002/gepi.1370100107

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Article

A generalized estimating equations approach to fitting major gene models in segregation analysis of continuous phenotypes.

Genetic epidemiology - 1 Jan 1993

Lee H, Stram D O, Thomas D C

Abstract excerpt

This paper discusses the application of estimating equations methods based on a quadratic exponential model [Prentice and Zhao, 1991] as a potential competitor with full likelihood approaches to estimating the effect of major genes in a segregation analysis [Elston, 1981] of continuous phenotypes...

Topics

Alleles
Analysis of Variance
Female
Gene Frequency
Genotype
Humans
Likelihood Functions
Male
Mathematics
Models, Genetic
Pedigree
Phenotype
Regression Analysis

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