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Article

Gamma regression improves Haseman-Elston and variance components linkage analysis for sib-pairs.

Genetic epidemiology - 1 Feb 2004

Barber Mathew J, Cordell Heather J, MacGregor Alex J, Andrew Toby

Abstract excerpt

Existing standard methods of linkage analysis for quantitative phenotypes rest on the assumptions of either ordinary least squares (Haseman and Elston [1972] Behav. Genet. 2:3-19; Sham and Purcell [2001] Am. J. Hum. Genet. 68:1527-1532) or phenotypic normality (Almasy and Blangero [1998] Am. J. Hum. Genet. 68:1198-1199; Kruglyak and Lander [1995] Am. J. Hum. Genet. 57:439-454). The limitations of both these...

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PMID: 14748009
DOI: 10.1002/gepi.10299

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