Testing association between candidate-gene markers and phenotype in related individuals, by use of estimating equations.

Abstract excerpt

Association studies are one of the major strategies for identifying genetic factors underlying complex traits. In samples of related individuals, conventional statistical procedures are not valid for testing association, and maximum likelihood (ML) methods have to be used, but they are computationally demanding and are not necessarily robust to violations of their assumptions. Estimating equations (EE) offer an...

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