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Article

Variance components/major locus likelihood approximation for quantitative, polychotomous, and multivariate data.

Genetic epidemiology - 1 Jan 1993

Hasstedt S J

Abstract excerpt

Pearson [Philos Trans R Soc Lond [A] 200:1-66, 1903], Mendell and Elston [Biometrics 30:41-57, 1974], and Rice et al. [Biometrics 35:451-459, 1979] approximated the likelihood of the multifactorial model on a dichotomous phenotype by a procedure of successive univariate computation and conditioning. Hasstedt [Pap: Pedigree Analysis Package, Rev. 3. 1989] and Demenais [Am J Hum Genet 49:773-785, 1991] extended the...

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PMID: 8349098
DOI: 10.1002/gepi.1370100302

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