Article
Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1993
Church S L, Grant J W, Ridnour L A, Oberley L W, Swanson P E, Meltzer P S, Trent J M
Abstract excerpt
Introduction of a normal human chromosome 6 into human melanoma cell lines results in suppression of tumorigenicity. This suggests that a gene(s) on chromosome 6 controls the malignant phenotype of human melanoma. Because antioxidants can suppress the tumor-promotion phase of carcinogenesis, and...
Topics
- Base Sequence
- Blotting, Southern
- DNA
- DNA, Antisense
- Fluorescent Antibody Technique
- Humans
- Isoenzymes
- Kinetics
- Melanoma
- Molecular Sequence Data
- Oligodeoxyribonucleotides
- Phenotype
- Polymerase Chain Reaction
- Superoxide Dismutase
- Transfection