Article
Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1993
Church S L, Grant J W, Ridnour L A, Oberley L W, Swanson P E, Meltzer P S, Trent J M
Abstract excerpt
Introduction of a normal human chromosome 6 into human melanoma cell lines results in suppression of tumorigenicity. This suggests that a gene(s) on chromosome 6 controls the malignant phenotype of human melanoma. Because antioxidants can suppress the tumor-promotion phase of carcinogenesis, and because the antioxidant enzyme manganese superoxide dismutase (MnSOD) has been localized to a region of chromosome 6...
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