Article
Melanoma-derived interleukin 6 inhibits in vivo melanoma growth.
The Journal of investigative dermatology - 1 Mar 1994
Armstrong C A, Murray N, Kennedy M, Koppula S V, Tara D, Ansel J C
Abstract excerpt
Malignant melanomas are capable of producing a wide range of cytokines with multiple biologic functions, including interleukin 6 (IL-6). We have observed an inverse relationship between IL-6 production of three B16-derived murine melanoma cell lines (NP133, HFH18, and HFH(M)) and the tumorigenicity of these melanoma cells in syngeneic mice. To further test the effect of IL-6 on melanoma growth, a...
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