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Manganese Superoxide Dismutase Is a <i>p53</i> -Regulated Gene That Switches Cancers between Early and Advanced Stages

18 Oct 2011

Abstract excerpt

Manganese superoxide dismutase (MnSOD) plays a critical role in the survival of aerobic life, and its aberrant expression has been implicated in carcinogenesis and tumor resistance to therapy. However, despite extensive studies in MnSOD regulation and its role in cancer, when and how the alteration of MnSOD expression occurs during the process of tumor development in vivo are unknown. Here, we generated...

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PMID: 22009531
DOI: 10.1158/0008-5472.can-11-1233

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