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MnSOD up-regulates maspin tumor suppressor gene expression in human breast and prostate cancer cells.

Antioxidants & redox signaling - 1 Oct 2003

Duan Hong, Zhang Hannah J, Yang Ji-Qin, Oberley Larry W, Futscher Bernard W, Domann Frederick E

Abstract excerpt

Manganese superoxide dismutase (MnSOD) is an antioxidant enzyme with tumor suppressor activity; however, the molecular mechanisms of MnSOD antitumor effects remain unclear. We hypothesized that MnSOD activity in cancer cells might cause downstream changes in the expression of other tumor suppressor genes. To determine whether maspin, a tumor suppressor gene that inhibits breast cancer cell invasion and...

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PMID: 14580325
DOI: 10.1089/152308603770310356

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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